Immunological studies in congenital nephrosis.
نویسندگان
چکیده
منابع مشابه
Enzymatic activity of the isolated glomerulus in normal and nephrotic rats.
Recent studies of the nephrotic kidney have implicated the glomerulus as the primary anatomic site of injury. Using the electron microscope, Farquhar, Vernier and Good (1) and other investigators have demonstrated that the most consistent and striking alteration is a lesion in the foot process of the glomerular epithelial cell. Hjelt, Stjernvall and Hallman (2), in a study of congenital nephros...
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Studies of Mendelian forms of focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome have provided new insights into the mechanism of these diseases. Congenital nephrotic syndrome and familial forms of FSGS form a spectrum of podocyte diseases of varying severity and age of onset. Mutations in both nephrin gene (NPHS1) alleles lead to congenital nephrosis, podocyte foot process efacem...
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Nephrotic syndrome (NS) in children includes a diverse group of diseases that range from genetic diseases without any immunological defects to causes that are primarily due to immunological effects. Recent advances in molecular and genomic studies have resulted in a plethora of genetic defects that have been localized to the podocyte, the basic structure that is instrumental in normal filtratio...
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LANGE, K., WACHSTEIN, M., WASSERMAN, E., ALPTEKIN, F. & SLOBODY, L.B. (1963) The congenital nephrotic syndrome, an immune reaction? American Journal of Diseases of Children, 105, 338. MCDONALD, R., WIGGELINKHUIZEN, J. & KASHULA, R. (1971) The nephrotic syndrome in very young infants. American Journal of Diseases of Children, 122, 507. NORIo, R. (1966) Heredity in the congenital nephrotic syndro...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 9 2 شماره
صفحات -
تاریخ انتشار 1972